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In summary, both the AGc and the p[v-a]CO2 are indirect assessments of intracellular pH within the cells of the lethal corner. The increasing magnitude of either parameter is indicative of a lethal intracellular acidosis that is not necessarily detected by conventional blood gas or electrolyte interpretation.
The Viability Index (VI) can quantify the magnitude of the shock that the patient is experiencing. Internal, iatrogenic or perfusionist directed compensation mechanisms may normalize blood gas values and vital signs without actually improving the lethal intracellular acidosis of the lethal corner. In theory, the greater the VI the larger the lethal corner and the more severe the shock. So understanding the principles of the Oxygen Pressure Field and the VI may help the perfusionist to develop perfusion strategies more likely to result in a favorable outcome.

Perfusion Theory is an educational platform for the Oxygen Pressure Field Theory (OPFT). August Krogh’s theoretical concept of the oxygen pressure field is explained and then applied to clinical applications in perfusion practice.