Session 4: Breaking the Reperfusion Barrier: Perfusion’s 21st Century Challenge

  1. Becker LB, New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovascular Research 61 (2004);461 470
  2. http://www.benbest.com/cryonics/ischemia.html#reperfuse
  3. http://www.thoracic.org/sections/clinical-information/critical-care/critical-care-research/animal-models-of-acute-lung-injury.html
  4. Mura et al. Critical Care 2006 10:R130
  5. Lamia B, Minerva Anestesiol 2006
  6. Schneider D. Limits of resuscitation. I. Thanatophysiologic and therapeutic limits. Z Gesamte Inn Med. 1981 May 15;36(10):305-10.
  7. AHA Circulation, 2005. 112(24 Suppl): p. IV1-203.
  8. AHA Pediatrics, 2006. 117(5): p. e989-1004.
  9. Idris AH et al. Crit Care Med 2005; 33(9):2043-8.
  10. Becker, L.B.,Cardiovasc Res, 2004. 61(3): p. 461-70.
  11. KH Polderman, Crit Care Med 2009 37:7(Suppl), S188
  12. Nozari A, Safar P, Stezoski SW, et al. Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. Circulation. Jun 13 2006;113(23):2690-2696.
  13. Wang et al. Journal of Cerebral Blood Flow & Metabolism (2002) 22, 206–214; doi:10.1097/00004647-200202000-00008
  14. Muehlschlegel S, Sims JR. Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit. Neurocrit Care 2009;10:103-15.
  15. Morris MC, Wernovsky G, Nadkarni VM. Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrest. Pediatr Crit Care Med 2004;5:440-6.
  16. Chen YS, Lin JW, Yu HY, et al. Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis. Lancet 2008;372:554-61.
  17. Cabanas JG, Brice JH, De Maio VJ, Myers B, Hinchey PR. Field-induced Therapeutic Hypothermia for Neuroprotection after Out-of Hospital Cardiac Arrest: A Systematic Review of the Literature. J Emerg Med.
  18. Grist G, Whittaker C, Merrigan K, Fenton J, Pallotto E, Lofland G. Defining the late implementation of extracorporeal membrane oxygenation (ECMO) by identifying increased mortality risk using specific physiologic cut-points in neonatal and pediatric respiratory patients. J Extra Corpor Technol 2009;41:213-9
  19. Grist G, Whittaker C, Merrigan K, et al. Identifying neonatal and pediatric cardiac and congenital diaphragmatic hernia extracorporeal membrane oxygenation patients at increased mortality risk. J Extra Corpor Technol;42:183-90.
  20. Halestrap AP. Calcium, mitochondria and reperfusion injury: a pore way to die. Biochem Soc Trans 2006;34:232-7.

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Perfusion Theory is an educational platform for the Oxygen Pressure Field Theory (OPFT). August Krogh’s theoretical concept of the oxygen pressure field is explained and then applied to clinical applications in perfusion practice.

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