The Anion Gap: BUN Correction Factor

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The BUN correction factor for the AG was determined by multiple observations in almost 300 ECMO patients. This table illustrates how the BUN correction factor can be applied. The corrected anion gap (AGc) is the number resulting from the application of the albumin and BUN correction factors to the normal AG measurement. These corrections improve the predictive power of the AG and make it a valuable tool for perfusionists attempting to assess for the presence of an anoxic lethal corner.
The AGc has the advantage over lactate measurements in that peak lactate values often lag behind the peak AGc by about 2 hours. So decisions concerning effective interventional strategies can be made sooner if the AGc is serially monitored.

Perfusion Theory is an educational platform for the Oxygen Pressure Field Theory (OPFT). August Krogh’s theoretical concept of the oxygen pressure field is explained and then applied to clinical applications in perfusion practice.